Question 1

If I use peptide, do I have to stop antibiotics?

Accepted Answer

PEPTIDE‑PRO is a feed additive, not a treatment drug, so it doesn't replace a technician's treatment protocol. Its correct use is preventive: keeping Vibrio pressure low so disease doesn't flare up in the first place. Worth noting: the two don't conflict. The peptide punches through the bacterial membrane, which makes it easier for treatment drugs to get inside; Peptobiotics' testing recorded better Vibrio inhibition when the two were used together versus alone. That said, dosing and combination decisions still need to be made by a technician based on the pond's condition — don't combine them on your own.

Question 2

Why is it harder for bacteria to develop resistance to peptide than to antibiotics?

Accepted Answer

Antibiotics typically lock onto one enzyme or one specific target inside the bacterium. A mutation at exactly that target is enough to dodge it. Antimicrobial peptides instead punch straight through the cell membrane — to dodge that, the bacterium has to change its membrane structure, which is far more costly and usually leaves it weaker. To be precise: this is harder, not impossible. Reduced peptide sensitivity has been recorded in bacteria under lab conditions. What's reassuring is that this molecule class has kept its effectiveness across hundreds of millions of years of evolution inside animal immune systems.

Question 3

Does it also kill the beneficial bacteria in the shrimp gut?

Accepted Answer

Antimicrobial peptides discriminate by membrane surface charge. Many pathogenic bacteria carry a strongly negative membrane charge, which attracts the positively-charged peptide; beneficial-bacteria membranes and shrimp cell membranes differ in composition and bind it less. According to Peptobiotics' dossier, the active ingredient inhibits every Vibrio strain tested without harming the beneficial microbiome.

Question 4

Can it be mixed with digestive enzymes?

Accepted Answer

Check whether that enzyme contains protease. Protease cleaves protein chains, and the active ingredient in PEPTIDE‑PRO is itself an amino-acid chain — mixing the two will reduce effectiveness. Enzymes without protease aren't a problem. If you're not sure, separate the feeding times or call technical support.

Question 5

How much does a 20 kg bag cover for a pond?

Accepted Answer

Calculate based on feed volume, not pond area. At the 5 g/kg maintenance dose, one 20 kg bag covers 4 tonnes of feed. A pond feeding 100 kg/day would get roughly 40 days out of one bag. Use the calculator in the Usage guide section to get the number for your own pond.

Question 6

Does the product leave residue at harvest?

Accepted Answer

The active ingredient is an amino-acid chain — the same basic nature as the protein in feed — so it's digested and broken down rather than accumulating in shrimp meat the way an antibiotic molecule does. The label states clearly: no antibiotics, no resistance, no residue.

Antimicrobial peptidefrom marine-organism genes

In many farming regions, Vibrio has already developed resistance to several antibiotics at once

See the mechanism of action, trial data, and detailed dosing

Seeing signs of Vibrio in your pond? Call technical support before you buy.

Ask Than Vuong