High-density pangasius easily breaks out with bacillary necrosis (Edwardsiella ictaluri) and hemorrhage when the pond environment turns bad. Than Vuong: stabilize environment + protect liver + treat the right agent.
Successful grow-out pangasius needs: (1) managing the high-density pond — water exchange, bottom probiotics (SOILMAX New, MAX 4000), NH3/NO2 removal (YUCCA C); (2) liver and gut protection with HERB GUARD, MAX LIVER, PRO GUT plus immunity boosters AQUAMOS/BETAGLUCAN; (3) on disease: treat Edwardsiella ictaluri necrosis with FLOR-MAX, Aeromonas hemorrhage with OXYTETRA/DOXYPA, parasites with AQUA PRAZI — always observe the pre-harvest withdrawal period.
Pangasius is raised in high-density earthen/floating ponds on pellets. Organic load and FCR decide profit — a bad environment weakens the liver, invites disease and spikes FCR.
Excess feed and feces build up, raising NH3/NO2/H2S and lowering bottom oxygen. Water exchange + bottom probiotics + toxic-gas removal keep the pond stable and the liver healthy.
Bacillary necrosis (Edwardsiella ictaluri) and Aeromonas hemorrhage cause mass mortality. Identify the agent to use antibiotics effectively and avoid resistance.
The liver is the most stressed organ in high-density pangasius. Protecting liver + gut + regular immune support helps fish cope, feed strongly and reduces antibiotic use.
Regular SOILMAX New + MAX 4000 for the bottom; apply YUCCA C when gas is high; exchange water + boost oxygen.
Feed HERB GUARD + MAX LIVER + PRO GUT to protect liver and gut; CANFORTA for vitamins and appetite.
AQUAMOS + BETAGLUCAN GRO regularly, intensified at season change or environmental swings.
Cut feed, use FLOR-MAX for Edwardsiella ictaluri per dose, with HERB GUARD for liver recovery.
OXYTETRA / DOXYPA for Aeromonas; AQUA PRAZI for parasites; disinfect with WORK 80 / POWER GLUTA. Observe pre-harvest withdrawal.
SOILMAX NewConcentrated bottom probiotics, decompose organics, cut toxic gas
MAX 4000Broad-salinity probiotics, strong at low-oxygen bottom, cut NH3/NO2/H2S
NIAZYMEClean water & bottom, remove toxic gas, build water color
AQUA PRO4000XBroad-salinity probiotics treat bottom/water, control algae — fresh & marine
UNPARA ABIProbiotics clean the pond bottom, decompose detritus, build good water color
YUCCA CFast NH3 absorption, anti-shock, stabilize environment
NITROBACYucca extract absorbs ammonia, speeds nitrification
AQUA BLOCKSettle silt & dead algae, cut toxic gas, clarify pond water
PREMIX EDTAChelate heavy metals, reduce acid-sulfate (iron, aluminum, manganese)
CANFORTAHigh-uptake vitamins & amino acids, boost appetite and immunity
CALPHOS GROMinerals for growth and skeletal development
QUICKSHELL GOLDMinerals + iron for fast blood formation, aid recovery
GROWMINPremium Mg-Ca minerals, stabilize alkalinity and pH
MIXBOOMSupply minerals, stabilize the environment, reduce stress
PRO GUTPrevent gut disease, neutralize toxins, restore gut wall
BIOMAXYeast boosts immunity, balances gut microbiome
AQUAMOSYeast nutrients stimulate immunity, healthy gut, faster growth
BETAGLUCAN GROBeta-glucan boosts health, stimulates natural immunity
CLEVERSuppress opportunistic gut bacteria (Vibrio)Use under guidance, observe withdrawal period.
FLOR-MAXFlorfenicol for bacillary necrosis (Edwardsiella ictaluri)
OXYTETRATreats Aeromonas/Pseudomonas hemorrhage; Vibrio luminescence
DOXYPABroad-spectrum doxycycline for severe infection
TETRA MAXTreats Aeromonas gut hemorrhageTETRA-CAntibiotic + vitamin C — treat infection, support immunity
AQUA PRAZITreats parasites: monogeneans, gill flukes, fish liceClick to read the full translation. Open-access papers fully translated; copyrighted papers summarized from abstract.
Liaqat et al., 2024, PLoS ONE
Finding: Dietary Bacillus subtilis at 1×10¹⁰ CFU/g nearly doubled weight (398 vs 218 g), cut FCR 2.55→0.89, and raised post-challenge survival 40%→100%.
Different angle: Strong support: a single feed-added Bacillus strain boosts growth/FCR and resistance, fitting feed-probiotics for catfish grow-out.
Striped catfish under intensive culture face stress, disease and antibiotic overuse. Bacillus subtilis was tested as a single-strain feed probiotic over 8 weeks at P0–P3 (1×10⁶–10¹⁰ CFU/g), then challenged with Staphylococcus aureus.
1×10¹⁰ CFU/g was optimal, improving growth, feed efficiency, antioxidants and disease resistance.
Kumar, Das et al., 2022, Frontiers in Immunology
Finding: An Ichthyophthirius × Aeromonas hydrophila co-infection killed over 90% of fingerlings; 10 ppm turmeric oil roughly doubled survival and boosted immune/antioxidant markers.
Different angle: Aeromonas hemorrhage often co-occurs with parasites in cold/poor water; herbal additives plus water probiotics lower pathogen pressure.
A natural co-infection of Ichthyophthirius multifiliis and Aeromonas hydrophila killed over 90% of catfish fingerlings in cold water (16–20°C). A. hydrophila alone caused 100% mortality in 48 h. Turmeric oil at 10 ppm roughly doubled survival; SOD/catalase peaked, cortisol fell, HSP70/90 ~2-fold up, C3 ≥4-fold up. A herbal alternative to antibiotics for Aeromonas co-infection.
Erickson et al., 2024, Microorganisms (MDPI)
Finding: 30 Vietnamese E. ictaluri isolates belonged to one ST-26 lineage and widely carried resistance to florfenicol (77%), sulfonamides (77%), streptomycin (77%) and tetracycline (63%), with 30% ESBL-positive.
Different angle: BNP is catfish's top killer and now resists most common antibiotics — reinforcing proactive prevention via bottom/gas probiotics and liver-support additives.
Bacillary necrosis (BNP) from E. ictaluri is the most damaging catfish disease in the Mekong Delta. Of 72 isolates (2017–2021, 7 provinces), 30 were whole-genome sequenced: all were ST-26 (≥99% identity, ≤90 SNPs), carrying floR 77%, sul2 77%, streptomycin 77%, tetA 63%, ESBL 30%; 57% had T3SS, all had urease. A single resistant lineage circulates widely, warning of treatment failure and the need for non-antibiotic prevention.
2022, Aquaculture (Elsevier)
Finding: A multispecies probiotic improved growth, digestive enzymes, immunity, hepatic antioxidant activity and disease resistance in catfish fingerlings.
Different angle: A multispecies blend boosts growth and protects the liver — fitting liver-support plus digestive probiotics for catfish.
Translated from the abstract — full paper restricted by the publisher on the original page.
Published in Aquaculture, this study evaluated a multispecies probiotic feed additive in striped catfish fingerlings. Probiotic-fed fish showed improved growth, higher digestive enzymes, positively modulated immunity, raised hepatic antioxidant activity (liver protection) and higher survival on challenge. The blend is a useful additive improving growth, digestion, immunity, liver protection and disease resistance. (Paywalled — no numbers cited to avoid error.)
Bacillary necrosis from Edwardsiella ictaluri — treat with FLOR-MAX (florfenicol, low resistance) per dose, with HERB GUARD for liver recovery and reduced feeding during treatment. Observe full withdrawal before harvest.
Target FCR ~1.5–1.7. A rising FCR usually means weak liver, poor gut absorption or bad environment — protect the liver (HERB GUARD, MAX LIVER), stabilize the gut (PRO GUT) and treat the environment.
Apply SOILMAX New + MAX 4000 regularly to decompose the bottom and convert NH3/NO2; use YUCCA C or NITROBAC to absorb NH3 when high; increase water exchange and oxygen, especially late-crop.
Gill flukes, Trichodina, monogeneans → use AQUA PRAZI, combine with water disinfection by WORK 80 or POWER GLUTA, then re-seed probiotics.
Than Vuong technical team — free protocol consultation for your pond/cage, 24h response.
Aquaculture Q&A
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